I would like to add it be done at the Activity Level (e.g. for a particulary email). I likely want to be notified of all other activity, just not one particular activity that is being opened over and over again by Contact or any number of people copied on an email Activity.
One thousand times, yes – the ability to turn off notifications based on a contact name or email domain would be incredible. We do a lot of internal testing. Not being notified when our team is testing would save me about 20 emails per day.