Hi @PvPHS,
Yes, very possible. Your enrollment criteria would be that a Property Value Has Changed (Ticket Status). You can further refine that if needed, but essentially it would enroll after the evaluation and new ticket status is set.
You would then create branches for each of your rulesets. Based on the appropriate ruleset (branch) you would then assign the appropriate owner, or rotate between owners if more appropriate. Check out the screenshot below:
