Hi @hhiggins,
For our organisation, the need for a blanket working hours settings has mostly been for reporting purposes. As an example, one report would be a list of deals or tickets that haven’t had activity for 3 days, and this type of report would mostly work out of the box. On Mondays though, the report results would be skewed by the weekend. A workaround would be for the report to ignore Saturday and Sunday as these aren’t working days, but this isn’t currently a feature in HS.