Hey there @JMartin1094 - that’s such a good question. I’m hoping folks with more sequence sends than I’ve completed weigh in and offer real-world experience.
I teach clients my perspective, but it’s not backed up with hard data.
Like you, I’m a fan of threads if I’m trying to keep a conversation going with related information. But if I’m trying to tell multiple “stories” in my messaging, I’m going to not thread them so I can have new subject lines.
I also try to avoid the “RE: Subject line” hack it seems so many sales messages have. If I’ve never interacted with them, or at least sent one initial email, I don’t want it to look like I’m playing that trick.
Just my two cents.