Hi @robertkreisler,
Yes! You would create a first list of contacts which have received the marketing email. You can then create a second list, containing all contacts from the original recipient list of the email. Via the AND operator you would also say that contacts in this second list must not be a member of the first list.
In other words, you’re taking the original list and removing all contacts which have received the email.
Let me know if you have any follow-up questions!